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Think It’s Just a Headache? It Might Be Migraine Without Aura

Migraine without aura—commonly referred to as a “common migraine”—is the most prevalent form of migraine, accounting for approximately 75% of all cases. Unlike migraine with aura, this type lacks the early warning signs such as visual disturbances or sensory symptoms that some people experience before the onset of a headache.

Symptoms:

 

Symptoms of migraine without aura can vary significantly between individuals and even between attacks in the same person. Key symptoms include:

  • Pain on one side of the head (unilateral)
  • Throbbing or pulsing pain
  • Sensitivity to light (photophobia)
  • Sensitivity to sound (phonophobia)
  • Nausea and/or vomiting
  • Pain worsens with routine physical activity (e.g., walking or climbing stairs)
 

While some may experience only a few of these symptoms, others may face several during an episode, which typically lasts between 4 to 72 hours.

How Serious Is It?

 

Migraines without aura can range from moderately painful to severely disabling. In addition to causing significant disruptions in daily life, studies have shown that this type of migraine is associated with an increased risk of ischemic stroke, though the risk is higher in those with migraines with aura.

Causes and Risk Factors:

 

The exact cause of migraines remains unclear, but modern research suggests they result from a combination of genetic, neurological, hormonal, and environmental factors.

  1. Neuropeptides:One major factor is the activation of the trigeminal nerve, which releases pain-related neuropeptides like CGRP (calcitonin gene-related peptide). This release triggers inflammation and pain in the brain’s blood vessels.
  2. Estrogen Fluctuations:Hormonal changes, especially in estrogen levels, are a significant trigger. Women are more likely to suffer from migraines, particularly around menstruation, pregnancy, or menopause. Interestingly, it is often the fluctuation—not just low levels—of estrogen that leads to migraines.
  3. Serotonin Imbalance:Estrogen influences serotonin levels, a neurotransmitter associated with mood and pain regulation. A drop in serotonin levels may be a contributing factor in migraine development
  4. Genetics:Migraines tend to run in families. If one parent has migraines, there’s about 50% chance their child will too. If both parents are affected, that risk rises to 75%.

Menstrual Migraines:

Over half of all women with migraines experience attacks around their menstrual periods. These migraines typically occur in the days before, during, or just after menstruation. However, most individuals with menstrual migraines also experience them at other times during the month.

 

Diagnosis:

 

There is no definitive test for migraine without aura. Diagnosis is primarily based on clinical history and symptoms, following criteria from the International Classification of Headache Disorders (ICHD-3). A diagnosis is made when a person has experienced at least five attacks with the following features:

  • Lasting 4 to 72 hours
  • Having at least two of the following:
    • One-sided location
    • Pulsating pain
    • Moderate to severe intensity
    • Worsening with physical activity
  • Accompanied by at least one of the following:
    • Nausea and/or vomiting
    • Sensitivity to light and sound
 

Headache diaries and questionnaires like the POUND mnemonic or the ID Migraine tool can help healthcare providers confirm the diagnosis.

Though not diagnostic, imaging tests (e.g., MRI, CT scans) or blood tests may be performed to rule out other causes such as tumors, strokes, or neurological disorders.

Treatment Options:

Treatment for migraine without aura includes both acute (symptom relief) and preventive therapies.

Medications

 

Acute Treatments (used during a migraine attack):

 

  • NSAIDs: Ibuprofen (Advil), naproxen (Aleve)
  • Triptans: Sumatriptan (Imitrex), zolmitriptan (Zomig)
  • Gepants (CGRP receptor antagonists): Ubrelvy (Ubrogepant), Nurtec ODT (rimegepant), Zavzpret (zavegepant)
  • Anti-nausea medications: Metoclopramide or prochlorperazine
  • Dihydroergotamines: Migranal
  • Steroids: Dexamethasone, occasionally used to reduce recurrence
  • Nerve blocks: Administered in-clinic for severe, persistent attacks
 

Preventive Treatments (to reduce frequency and severity):

 

  • CGRP inhibitors: Vyepti (eptinezumab), Emgality (galcanezumab), Aimovig (erenumab), Ajovy (fremanezumab)
  • Nurtec ODT: The first medication approved by the FDA for both acute and preventive use
  • Antihypertensives: Propranolol, metoprolol, timolol
  • Antidepressants: Amitriptyline (Elavil), venlafaxine (Effexor)
  • Anticonvulsants: Topiramate (Topamax), divalproex sodium (Depakote)
  • Botox (onabotulinumtoxinA): Injected every 12 weeks into chronic migraines
 

Important Note:

 

Frequent use of acute medications can lead to medication-overuse headaches (rebound headaches). Always follow prescribed dosing guidelines.

Non-Medication Treatments:

 

Several FDA-cleared neuromodulation devices offer non-drug options for managing migraines:

  • tSNS: A headband device that stimulates forehead nerves to reduce headache frequency.
  • TMS (sTMS): A handheld device that delivers a magnetic pulse to the back of the head.
  • nVNS: A vagus nerve stimulator applied to the neck.
  • REN: A wearable device applied to the upper arm to interrupt pain pathways through electrical stimulation.
 

These therapies are particularly useful for people who prefer to avoid medications or cannot tolerate them.

Alternative Therapies:

 

  • Acupuncture
  • Massage
  • Supplements: Magnesium, riboflavin (vitamin B2), and coenzyme Q10
  • Biofeedback and Cognitive Behavioral Therapy (CBT)
 

Lifestyle Adjustment:

 

Effective migraine management goes beyond medication. Many people benefit from incorporating lifestyle adjustments into their daily routine.


  1. Improve Sleep Quality

 

Poor sleep is a common trigger. Helpful strategies include:

  • Maintaining a regular sleep schedule
  • Sleeping in a dark, cool, quiet room
  • Avoiding screens, caffeine, and alcohol before bed
 
  1. Identify and Avoid Triggers
 

A food and activity diary can help track potential triggers. Common ones include:

  • Alcohol (especially red wine)
  • Aged cheese and processed meats
  • MSG (monosodium glutamate)
  • Aspartame
  • Caffeine (both too much and withdrawal)

Note: Caffeine helps some people relieve migraines, so its effects can be individual.


  1. Manage Stress
 

Stress is one of the most significant migraine triggers. Techniques that may help include:

  • Yoga
  • Meditation
  • Deep breathing exercises
  • Regular physical activity
 

Scientific studies have shown mindfulness-based stress reduction can significantly reduce migraine frequency, severity, and impact on quality of life.


  1. Reduce Exposure to Visual Stimuli
 

Triggers may include:

  • Flickering or fluorescent lights
  • Glare from screens
  • Repetitive visual patterns
    Wearing tinted lenses or limiting screen time can help reduce exposure.
 

Coping and Support:

 

Living with migraines without an aura can be challenging. Attacks may lead to missed work, disrupted social plans, and emotional stress. Building a support system is crucial.

  • Join Support Groups: Online forums and local groups offer shared experiences and coping tips.
  • Workplace Adjustments: Consider requesting flexible schedules or reduced screen exposure.
  • Professional Guidance: Your healthcare provider can help create a personalized treatment plan and connect you with mental health or pain management resources.

 

Summary:

 

Migraine without aura is a common and often disabling neurological condition that affects millions. While symptoms and severity vary, effective treatments—both pharmaceutical and non-drug—are available. A combination of medications, lifestyle changes, and supportive care can significantly reduce migraine frequency and improve quality of life.

If you suspect you have migraines, consult a healthcare provider to receive a proper diagnosis and begin an individualized treatment plan.